S . Rossignol , G . Barrière , O . Alluin and A . Frigon Cord Injury Re - expression of Locomotor Function After Partial Spinal

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  • A. Frigon
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S . Rossignol , G . Barrière , O . Alluin and A . Frigon Spinal Cord Injury Re - expression of Locomotor Function After Partial

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Re-expression of locomotor function after partial spinal cord injury.

After a complete spinal section, quadruped mammals (cats, rats, and mice) can generally regain hindlimb locomotion on a treadmill because the spinal cord below the lesion can express locomotion through a neural circuitry termed the central pattern generator (CPG). In this review, we propose that the spinal CPG also plays a crucial role in the locomotor recovery after incomplete spinal cord injury.

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Spinal plasticity in the recovery of locomotion

Locomotion is a very robust motor pattern which can be optimized after different types of lesions to the central and/or peripheral nervous system. This implies that several plastic mechanisms are at play to re-express locomotion after such lesions. Here, we review some of the key observations that helped identify some of these plastic mechanisms. At the core of this plasticity is the existence ...

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Dual spinal lesion paradigm in the cat: evolution of the kinematic locomotor pattern.

The recovery of voluntary quadrupedal locomotion after an incomplete spinal cord injury can involve different levels of the CNS, including the spinal locomotor circuitry. The latter conclusion was reached using a dual spinal lesion paradigm in which a low thoracic partial spinal lesion is followed, several weeks later, by a complete spinal transection (i.e., spinalization). In this dual spinal ...

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Title: Dual Spinal Lesion Paradigm in the Cat: Evolution of the Kinematic Locomotor Pattern. 1 2

Title: Dual spinal lesion paradigm in the cat: evolution of the kinematic locomotor pattern. 1 2 Authors: Grégory Barrière*,, Alain Frigon*, Hugues Leblond, Janyne Provencher, 3 Serge Rossignol 4 * both authors contributed equally to this work. 5 6 7 Affiliation: Groupe de Recherche sur le Système Nerveux Central (FRSQ), Université de 8 Montréal, Department of Physiology, Montreal, Canada; Mult...

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تاریخ انتشار 2009